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The additive interaction of healthy lifestyles and genetic susceptibility on colorectal cancer risk in prediabetes: a large population-based prospective cohort study.

BMC gastroenterology - 18 Dec 2024

Wang Wenchen, Cheng Yikang, Meng Qingyu, Jia Baoqing, Yao Dawei, Cheng Yiping

Abstract excerpt

OBJECTIVE: We aimed to investigate the interrelationships among polygenic risk scores (PRS), healthy lifestyle factors (HLFs), and colorectal cancer (CRC) risk in individuals with prediabetes. To investigate whether adherence to HLFs influence CRC risk in those with elevated PRS within this specific population. METHODS: Data from 22,408 prediabetes participants without CRC at baseline were analyzed from the UK...

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Colorectal Neoplasms
Healthy Lifestyle
Multifactorial Inheritance
Prediabetic State

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

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PMID: 39696080
DOI: 10.1186/s12876-024-03552-w
PMCID: PMC11658106

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