Article
Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.
Cancer medicine - 1 May 2020
Xia Zhiyu, Su Yu-Ru, Petersen Paneen, Qi Lihong, Kim Andre E, Figueiredo Jane C, Lin Yi, Nan Hongmei, Sakoda Lori C, Albanes Demetrius, Berndt Sonja I, Bézieau Stéphane, Bien Stephanie, Buchanan Daniel D, Casey Graham, Chan Andrew T, Conti David V, Drew David A, Gallinger Steven J, Gauderman W James, Giles Graham G, Gruber Stephen B, Gunter Marc J, Hoffmeister Michael, Jenkins Mark A, Joshi Amit D, Le Marchand Loic, Lewinger Juan P, Li Li, Lindor Noralane M, Moreno Victor, Murphy Neil, Nassir Rami, Newcomb Polly A, Ogino Shuji, Rennert Gad, Song Mingyang, Wang Xiaoliang, Wolk Alicja, Woods Michael O, Brenner Hermann, White Emily, Slattery Martha L, Giovannucci Edward L, Chang-Claude Jenny, Pharoah Paul D P, Hsu Li, Campbell Peter T, Peters Ulrike
Abstract excerpt
BACKGROUND: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology. METHODS: To improve statistical power and interpretation for...
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