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Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study.

Psychological medicine - 1 Aug 2024

Wimberley Theresa, Brikell Isabell, Astrup Aske, Larsen Janne T, Petersen Liselotte V, Albiñana Clara, Vilhjálmsson Bjarni J, Bulik Cynthia M, Chang Zheng, Fanelli Giuseppe, Bralten Janita, Mota Nina R, Salas-Salvadó Jordi, Fernandez-Aranda Fernando, Bulló Monica, Franke Barbara, Børglum Anders, Mortensen Preben B, Horsdal Henriette T, Dalsgaard Søren

Abstract excerpt

BACKGROUND: Psychiatric disorders and type 2 diabetes mellitus (T2DM) are heritable, polygenic, and often comorbid conditions, yet knowledge about their potential shared familial risk is lacking. We used family designs and T2DM polygenic risk score (T2DM-PRS) to investigate the genetic associations between psychiatric disorders and T2DM. METHODS: We linked 659 906 individuals born in Denmark 1990-2000 to their...

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Comorbidity
Denmark
Diabetes Mellitus, Type 2
Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Disorders

Multifactorial Inheritance

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PMID: 38801094
DOI: 10.1017/S0033291724001053

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