Article
Excess Weight, Polygenic Risk Score, and Findings of Colorectal Neoplasms at Screening Colonoscopy.
The American journal of gastroenterology - 1 Sept 2024
Fu Ruojin, Chen Xuechen, Niedermaier Tobias, Seum Teresa, Hoffmeister Michael, Brenner Hermann
Abstract excerpt
INTRODUCTION: Excess weight is an established risk factor of colorectal cancer (CRC). However, evidence is lacking on how its impact varies by polygenic risk at different stages of colorectal carcinogenesis. METHODS: We assessed the individual and joint associations of body mass index (BMI) and polygenic risk scores (PRSs) with findings of colorectal neoplasms among 4,784 participants of screening colonoscopy....
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