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Article

Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.

Human genomics - 9 Jul 2025

Rosenthal Elisabeth A, Wei Wei-Qi, Luo Yuan, Namjou-Khales Bahram, Schaid Daniel J, Esplin Edward D, Lape Michael, Kottyan Leah, Pacheco Jennifer Allen, Weng Chunhua, Gordon Adam Samuel, Kullo Iftikhar J, Crosslin David R, Grady William M, Hsu Li, Peters Ulrike, Jarvik Gail P

Abstract excerpt

BACKGROUND: Many factors, including environmental and genetic variables, contribute to Colorectal Cancer (CRC) risk. The genetic components of risk can be divided into monogenic and polygenic factors. Just as monogenic factors can increase risk for more than one condition, polygenic factors may also underlie multiple phenotypes, including behavioral traits. In order to understand the biology of CRC risk better,...

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Identifiers

PMID: 40635049
DOI: 10.1186/s40246-025-00791-0
PMCID: PMC12239365

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