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Article

Deciphering the Genetic Underpinnings of Liver Cirrhosis-Heart Failure Comorbidity Through Multi-Omics: CRIM1 as a Key Endothelial Mediator.

International journal of molecular sciences - 6 Sept 2026

Zhao Ruiqi, Guo Jiesheng, Han Mengyao, Tang Shiqi, Hu Hui, Ma Mengqing, Sun Jialing, Zhou Xiaozhou

Abstract excerpt

The co-occurrence of liver cirrhosis (LC) and heart failure (HF) poses considerable clinical challenges, yet the cellular and molecular determinants of this comorbidity remain poorly characterized. To address this, we developed an integrative multi-omics pipeline encompassing GWAS meta-analysis, gsMap-based spatial transcriptomic projection, GeneEnrich functional annotation, single-cell atlas construction,...

Read the complete abstract on PubMed

Topics

Humans
Liver Cirrhosis
Heart Failure
Multiomics
Genome-Wide Association Study
Endothelial Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42737833
DOI: 10.3390/ijms27177936
PMCID: PMC13565823

Genes

CRIM1
LCP1
PTPRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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