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Article

Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits.

American journal of human genetics - 5 Sept 2024

Broadaway K Alaine, Brotman Sarah M, Rosen Jonathan D, Currin Kevin W, Alkhawaja Abdalla A, Etheridge Amy S, Wright Fred, Gallins Paul, Jima Dereje, Zhou Yi-Hui, Love Michael I, Innocenti Federico, Mohlke Karen L

Abstract excerpt

Understanding the molecular mechanisms of complex traits is essential for developing targeted interventions. We analyzed liver expression quantitative-trait locus (eQTL) meta-analysis data on 1,183 participants to identify conditionally distinct signals. We found 9,013 eQTL signals for 6,564 genes; 23% of eGenes had two signals, and 6% had three or more signals. We then integrated the eQTL results with data from...

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Identifiers

PMID: 39173627
DOI: 10.1016/j.ajhg.2024.07.017
PMCID: PMC11393674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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