Article

An integrated proteogenomic investigation of the human liver uncovers molecular drivers of steatotic liver disease

2026-06-06

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing worldwide, yet effective targeted therapies remain limited. To better understand the molecular mechanisms underlying MASLD, we performed an integrated proteogenomic analysis of human liver tissue. Using mass spectrometry, we quantified 2,744 proteins in 504 liver biopsies from the Quebec Obesity Biobank and examined changes acro...

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Literature Corpus work: 28ce37e0-19cf-5ee2-a8a1-72d822584144
DOI: 10.64898/2026.06.04.26354903

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