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Article

A Post-GWAS Analysis of the Shared Genetic Architecture Between COVID-19 and Coronary Artery Disease.

International journal of molecular sciences - 5 May 2026

Ali Muhammad Sarfraz, Haider Waseem, Aziz Sana, Mohammad Anwaruddin, Manichaikul Ani, Shi Weibin

Abstract excerpt

An individual's host genetics influence its susceptibility to both COVID-19 and coronary artery disease (CAD). We analyzed large-scale GWAS datasets encompassing 7.7 million SNPs to identify shared genetic architecture between the two diseases. We identified 24 pleiotropic risk loci for both COVID-19 and CAD, with three loci (1p31.1, 8p21.3, and 18q11.2) showing strong evidence for a single shared causal variant....

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Topics

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Share to Coronary Artery Disease
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 42123708
DOI: 10.3390/ijms27094132
PMCID: PMC13163323

Genes

CAD
DMTN
PIWIL2
AK5
CTAGE1
GATA6
PIGK
USP33
ZZZ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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