Article
Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets.
Genome medicine - 13 Feb 2026
Yao Wentao, Fan Jingyi, Lu Jing, Guo Haiyan, Yu Chengxiao, Wang Xuehui, Wang Yun, Zhang Yu, Duan Qingning, Cheng Lihua, Zhou Chen, Wang Zhaohui, Dai Juncheng, Ma Hongxia, Zhang Qun, Song Ci, Shen Hongbing
Abstract excerpt
BACKGROUND: Liver function-related quantitative biomarkers (LFQBs) are essential for assessing hepatic health, yet prior genome-wide association studies (GWAS) have largely studied them in isolation. We conducted cross-ancestry GWAS meta-analyses on seven LFQBs to further elucidate liver function’s genetic architecture, identify pleiotropic variants, and prioritize genes to pinpoint targets with therapeutic...
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