Article

Pan-fibrotic gene expression signature in major chronic diseases by integrative bulk and single-cell transcriptomic analyses

2025-10-08

Abstract excerpt

<h4>Background</h4> Fibrosis is a common pathological endpoint across multiple chronic diseases affecting organs, including the liver, kidney, and heart. Despite its prevalence and clinical burden, there are currently no robust validated molecular signatures that capture shared fibrotic mechanisms across organ systems. Herein, we present a comprehensive, human-based, cross-organ transcriptomic analysis that ident...

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Literature Corpus work: ba5a388e-3476-5ac2-b0b4-73a6a7630d12
DOI: 10.1101/2025.10.07.25337472

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