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Article

Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD.

Science advances - 13 Feb 2026

Du Mingyi, Yuan Huangbo, Wu Tianhao, Jiang Yanfeng, Suo Chen, Jin Li, Zhang Tiejun, Liu Zhenqiu, Chen Xingdong

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a globally prevalent disease, yet its genetic architecture remains incompletely characterized. We integrated genome-wide association study data from multiple cohorts totaling nearly 3 million individuals of European ancestry and applied cross-trait genomic modeling of hepatic fat and seven cardiometabolic traits to construct an MASLD-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41686896
DOI: 10.1126/sciadv.aeb5665
PMCID: PMC12904206

Genes

FRMD5
FURIN
NRXN3
PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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