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Article

NAFLD and Hypothyroidism: Deciphering Pivotal Genetic Variants, Cellular Expression Landscapes, and Spatial Architectures.

International journal of molecular sciences - 14 Feb 2026

Zhao Ruiqi, Han Mengyao, Lv Minling, Lin Sen, Wang Ximing, Li Jing, Sun Jialing, Zhou Xiaozhou

Abstract excerpt

Thyroid hormones profoundly modulate hepatic fatty acid and cholesterol synthesis and turnover. Although nonalcoholic fatty liver disease (NAFLD) shows epidemiological links to hypothyroidism, the genetic substrates of this relationship remain unresolved. Integrating large-scale genome-wide association studies with single-cell transcriptomics, spatial transcriptomics, and single-cell chromatin accessibility via...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41751988
DOI: 10.3390/ijms27041850
PMCID: PMC12941178

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MAGI3
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