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Article

Multi-omics and comprehensive multi-trait analysis identify shared genetic etiology of heart failure and related cancers.

Human genomics - 9 Dec 2025

Shui Wen, Wu Xianzhen, Liu Huiping, Li Zhilong, Zheng Guanghua

Abstract excerpt

BACKGROUND: Heart failure (HF) and cancer exhibit a significant bidirectional risk synergy, with their comorbidity forming a vicious cycle. Although the mechanisms of their pathological interactions have attracted considerable attention, their shared genetic determinants remain unclear. Therefore, this study integrates multi-omics data and employs multi-trait analytical approaches to investigate the genetic...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 41366697
DOI: 10.1186/s40246-025-00888-6
PMCID: PMC12801670

Genes

ERBB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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