Article
Spatiotemporal maps of CaMKII in dendritic spines.
Journal of computational neuroscience - 1 Aug 2012
Khan Shahid, Reese Thomas S, Rajpoot Nasir, Shabbir Ayisha
Abstract excerpt
The calcium calmodulin dependent kinase (CaMKII) is important for long-term potentiation at dendritic spines. Photo-activatable GFP (PaGFP) - CaMKII fusions were used to map CaMKII movements between and within spines in dissociated hippocampal neurons. Photo-activated PaGFP (GFP*) generated in the shaft spread uniformly, but was retained for about 1 s in spines. The differential localization of GFP*-CaMKII...
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