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Article

Multiple CaMKII Binding Modes to the Actin Cytoskeleton Revealed by Single-Molecule Imaging.

Biophysical journal - 26 Jul 2016

Khan Shahid, Conte Ianina, Carter Tom, Bayer K Ulrich, Molloy Justin E

Abstract excerpt

Localization of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to dendritic spine synapses is determined in part by the actin cytoskeleton. We determined binding of GFP-tagged CaMKII to tag-RFP-labeled actin cytoskeleton within live cells using total internal reflection fluorescence microscopy and single-molecule tracking. Stepwise photobleaching showed that CaMKII formed oligomeric complexes....

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Identifiers

PMID: 27463141
DOI: 10.1016/j.bpj.2016.06.007
PMCID: PMC4968397

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