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Article

Interactions between αCaMKII and calmodulin in living cells: conformational changes arising from CaM-dependent and -independent relationships.

Molecular brain - 19 Aug 2013

Kato Ken-ichi, Iwamoto Taku, Kida Satoshi

Abstract excerpt

BACKGROUND: αCaMKII plays central and essential roles in long-term potentiation (LTP), learning and memory. αCaMKII is activated via binding with Ca²⁺/CaM in response to elevated Ca²⁺ concentration. Furthermore, prolonged increase in Ca²⁺ concentration leads to the auto-phosphorylation of αCaMKII at T286, maintaining the activation of αCaMKII even after Ca²⁺/CaM dissociation. Importantly, the active form of...

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PMID: 23958294
DOI: 10.1186/1756-6606-6-37
PMCID: PMC3765210

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