Article
A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity.
Nature communications - 28 Aug 2026
Gahlot Deepanshi, Castin Jesu, Mathur Shruti, Das Debajyoti, Kumar Ajit, Arun Akanksha, Gain Chandrima, Sharma Mridul, Pal Ravi Kant, Jain Niyati, Biswal Bichitra K, Singh Rajat, Thukral Lipi
Abstract excerpt
Membrane recruitment is a fundamental regulator of protein function. However, the allosteric mechanisms by which lipid binding controls protein activity remain poorly understood. In autophagy, the ubiquitin-like protein LC3 is lipid-anchored to autophagosomes, where it is essential for receptor recruitment and vesicle formation. While LC3-receptor interactions are structurally well defined, how membrane...
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