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Article

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.

Autophagy - 1 Dec 2016

Kuang Yao, Ma Kaili, Zhou Changqian, Ding Pengfei, Zhu Yushan, Chen Quan, Xia Bin

Abstract excerpt

Mitophagy is a fundamental process that determines mitochondrial quality and homeostasis. Several mitophagy receptors, including the newly identified FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific interaction with LC3. However, the precise mechanism by which this interaction is regulated to initiate mitophagy is not understood. Here, we report the solution...

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Source

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Identifiers

PMID: 27653272
DOI: 10.1080/15548627.2016.1238552
PMCID: PMC5173264

Genes

FUNDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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