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Article

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux

10 Feb 2025

Abstract excerpt

During autophagy, toxic cargo is encapsulated by autophagosomes and trafficked to lysosomes for degradation. NBR1, an autophagy receptor targeting ubiquitinated aggregates, serves as a model for studying the multivalent, heterotypic interactions of cargo-bound receptors. Here, we find that three critical NBR1 partners-ATG8-family proteins, FIP200, and TAX1BP1-each bind to distinct, overlapping determinants within...

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PMID: 39928048
DOI: 10.1083/jcb.202407105

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