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Article

The rapidly expanding role of LC3-interacting regions in autophagy

24 Jul 2025

Abstract excerpt

LC3-interacting regions (LIRs), or Atg8-interacting motifs (AIMs), are short linear motifs found in unstructured loops or intrinsically disordered regions of many autophagy-related proteins. LIRs were initially identified for their role in binding to Atg8 family proteins on autophagosomal membranes. However, emerging evidence suggests that LIRs and their surrounding residues mediate interactions with a wide array...

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PMID: 40704964
DOI: 10.1083/jcb.202504076

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