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Article

The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer.

Autophagy - 1 Oct 2021

Fas Burcu Aykac, Maiani Emiliano, Sora Valentina, Kumar Mukesh, Mashkoor Maliha, Lambrughi Matteo, Tiberti Matteo, Papaleo Elena

Abstract excerpt

Macroautophagy/autophagy is a cellular process to recycle damaged cellular components, and its modulation can be exploited for disease treatments. A key autophagy player is the ubiquitin-like protein MAP1LC3B/LC3B. Mutations and changes in MAP1LC3B expression occur in cancer samples. However, the investigation of the effects of these mutations on MAP1LC3B protein structure is still missing. Despite many LC3B...

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Identifiers

PMID: 33302793
DOI: 10.1080/15548627.2020.1847443
PMCID: PMC8525936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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