Article

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

2026-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and structural studies have identified LIRs in many LC3B interaction partners, but the sequence features that contribute to binding have not been systematically explored. To discover peptides that interac...

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Literature Corpus work: 16ee6caf-ee8e-56f7-a0dc-97597aa994a4
DOI: 10.64898/2026.01.05.697675

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