Development of mitochondrial mutator pigs exhibiting increased mitochondrial DNA mutations and premature aging via prime editing.

doi:10.1126/sciadv.adu0632

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Article

Development of mitochondrial mutator pigs exhibiting increased mitochondrial DNA mutations and premature aging via prime editing.

Science advances - 28 Aug 2026

Chen Fangbing, Liang Yanhui, Zheng Wei, Yao Aobo, Wang Ning, Chen Huangyao, Zhuang Zhenpeng, Lian Meng, Zhao Yu, Ouyang Zhen, Zhou Zhaohai, Ge Weikai, Liu Qishuai, Ye Yinghua, Lai Liangxue, Wang Kepin

Abstract excerpt

The accumulation of mitochondrial DNA (mtDNA) mutations is a primary driver of mitochondrial dysfunction, which is intrinsically linked to aging and various pathologies. POLG, the catalytic subunit of DNA polymerase gamma, is essential for mtDNA replication; notably, a deficiency in its proofreading function precipitates the accumulation of mtDNA mutations. In this study, by combining prime editing with somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42647635
DOI: 10.1126/sciadv.adu0632
PMCID: PMC13510606

Genes

POLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.