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Article

Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model.

Genetics - 1 Mar 2016

Cagnone Gael, Tsai Te-Sha, Srirattana Kanokwan, Rossello Fernando, Powell David R, Rohrer Gary, Cree Lynsey, Trounce Ian A, St John Justin C

Abstract excerpt

The maternally inherited mitochondrial genome (mtDNA) is present in multimeric form within cells and harbors sequence variants (heteroplasmy). While a single mtDNA variant at high load can cause disease, naturally occurring variants likely persist at low levels across generations of healthy populations. To determine how naturally occurring variants are segregated and transmitted, we generated a mini-pig model,...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26819245
DOI: 10.1534/genetics.115.181321
PMCID: PMC4788130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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