Article

3D Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion

2026-02-11

Abstract excerpt

<h4> A bstract </h4> <h4>Background</h4> Transthyretin amyloidosis (ATTR) is a progressive, degenerative disease affecting the heart and other organ systems, as well as the peripheral, autonomic, and central nervous systems. Although pharmacological and genetic evidence establishes aggregation as a driver of ATTR pathology, the mechanism by which aggregation compromises post-mitotic tissue function is poorly u...

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Literature Corpus work: 0c50d91f-b706-5352-9ae9-aafd0a8e36bb
DOI: 10.64898/2026.02.09.704431

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