Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4+ T cells.

doi:10.1016/j.immuni.2026.08.001

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Article

Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4+ T cells.

Immunity - 8 Sept 2026

Jay Atishay, Zhou Yeqiao, Yoon Sora, Abeje Bereketab N, Chandra Aditi, Michieletto Michael F, Wald Julia, Henao-Mejia Jorge, Raj Arjun, Faryabi Robert B, Vahedi Golnaz

Abstract excerpt

Naive CD4+ T cells interpret cytokine cues to commit to T helper lineages. Here, we examined the impact of cytokines on the Ets1-Fli1 locus, which encodes paralogous transcription factors essential for T cell effector responses. Epigenomic and chromatin interaction profiling in double-positive (DP) thymocytes defined a T cell super-enhancer and a CTCF-bound boundary. Chromatin tracing at single-allele resolution...

Read the complete abstract on PubMed

Topics

Animals
Super Enhancers
Proto-Oncogene Protein c-ets-1
Chromatin
Mice
Cytokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proto-Oncogene Protein c-fli-1

Alleles

CD4-Positive T-Lymphocytes

CCCTC-Binding Factor

Th1 Cells

Gene Expression Regulation

Thymocytes

Mice, Inbred C57BL

Enhancer Elements, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42636801
DOI: 10.1016/j.immuni.2026.08.001
PMCID: PMC13529062

Genes

CD4
CTCF

Provenance

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