Article
Leucine-rich repeat kinase 2-related functions in GLIA: an update of the last years.
Biochemical Society transactions - 30 Jun 2021
Filippini Alice, Gennarelli Massimo, Russo Isabella
Abstract excerpt
Missense mutations in the leucine-rich repeat kinase-2 (LRRK2) gene represent the most common cause of autosomal dominant Parkinson's disease (PD). In the years LRRK2 has been associated with several organelles and related pathways in cell. However, despite the significant amount of research done in the past decade, the contribution of LRRK2 mutations to PD pathogenesis remains unknown. Growing evidence...
Topics
- Animals
- Astrocytes
- Brain
- Genetic Predisposition to Disease
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Microglia
- Mutation, Missense
- Parkinson Disease
- Signal Transduction