Article

Parkinson’s Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance

2020-10-26

Abstract excerpt

<h4>Background: </h4> Parkinson’s disease (PD) is a neurodegenerative, progressive disease without cure. To prevent PD onset or at least limit neurodegeneration, a better understanding of the underlying cellular and molecular disease mechanisms is crucial. Mutations in the leucine rich repeat kinase 2 ( LRRK2 ) gene represent one of the most common causes of familial PD. In addition, LRRK2 variants are risk factor...

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Literature Corpus work: 1a24dffd-b991-5626-bcce-2a9a1464a151
DOI: 10.21203/rs.3.rs-95404/v1

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