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Article

AID self-assembly and multistranded DNA binding drive synapsis in class switch recombination.

Nucleic acids research - 10 Aug 2026

Liu Di, Zhang Chenyang, He Yuhang, Zhu Hongtao, Qi Keyin, Dong Yanying, Zhao Bailin

Abstract excerpt

Activation-induced deaminase (AID) initiates immunoglobulin class switch recombination (CSR) by deaminating cytosines within transcription-generated single-stranded DNA in switch regions. R-loops formed during switch-region transcription are thought to expose AID substrates; however, how AID engages and organizes these complex nucleic acid structures remain unclear. Here, combining ensemble biochemistry with...

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Identifiers

PMID: 42626843
DOI: 10.1093/nar/gkag806
PMCID: PMC13494559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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