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Article

Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2016

Mondal Samiran, Begum Nasim A, Hu Wenjun, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. Although both the N and C termini of AID have unique functions in DNA cleavage and recombination, respectively, during SHM and CSR, their molecular mechanisms are poorly understood. Using a bimolecular fluorescence complementation (BiFC) assay combined with glycerol...

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Identifiers

PMID: 26929374
DOI: 10.1073/pnas.1601678113
PMCID: PMC4801308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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