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Article

AID Recognizes Structured DNA for Class Switch Recombination.

Molecular cell - 3 Aug 2017

Qiao Qi, Wang Li, Meng Fei-Long, Hwang Joyce K, Alt Frederick W, Wu Hao

Abstract excerpt

Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting and catalysis remain elusive despite its critical immunological roles and off-target effects in tumorigenesis. Here, we produced active human AID and revealed its preferred recognition and deamination of structured substrates....

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28757211
DOI: 10.1016/j.molcel.2017.06.034
PMCID: PMC5771415

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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