Article
hnRNPK condensates facilitate enhancer-promoter looping and RNA polymerase II recruitment.
Nature genetics - 1 Sept 2026
Ye Rong, Zhao Hailian, Chen Juan, Wu Qigui, Wang Di, Cai Zhaokui, Wang Ruoyan, Li Jingxin, Cheng Tiantian, Zhang Ming, Liu Wanglong, Yang Ruiyun, Zhou Jie, Yuan Zhen, Liu Bowen, Cao Changchang, Zhu Shuoji, Li Xing, Li Jinsong, Zhang Tengfei, Zhu Ping, Xue Yuanchao
Abstract excerpt
Enhancer RNAs interact with promoter-derived RNAs to dictate enhancer-promoter looping, but the RNA-binding protein that mediates this process has remained unidentified. Here we identify hnRNPK as a general structural regulator that preferentially binds to nascent RNAs transcribed from enhancer and promoter regions, promoting enhancer-promoter looping and transcriptional activation. We further show that hnRNPK...
Read the complete abstract on PubMedTopics
- RNA Polymerase II
- Animals
- Promoter Regions, Genetic
- Enhancer Elements, Genetic
- Mice