DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers

Abstract excerpt

BACKGROUND: Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer-promoter interaction are incompletely understood. G-quadruplex DNA secondary structures (G4s) have recently been shown to co-occur with 3D chromatin interactions; however, the functional importance of G4s within enhancers remains unclear. RESULTS: In this study, we identify...

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