RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant chromatin-associated condensates have emerged as drivers of transcriptional dysregulation in cancer. Although extensive studies have elucidated intrinsic protein sequence features governing their formation, how extrinsic factors within the chromatin environment modulate their assembly and pathogenic function remains poorly understood. Gain-of-function mutations in the histone acetylatio...

Topics

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• Carcinogenesis
• Chromatin
• Gene Expression Regulation, Neoplastic
• Mice
• Mutation
• Protein Binding
• RNA
• Transcription, Genetic

Identifiers and source

Literature Corpus work

04b1afce-268f-5177-a849-cad5630fedc9

DOI

10.1101/2025.07.29.665963