Article

RNA polymerase II clustering through CTD phase separation

2018-05-07

Abstract excerpt

The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered low-complexity region that is critical for pre-mRNA transcription and processing. The CTD consists of hepta-amino acid repeats varying in number from 52 in humans to 26 in yeast. Here we report that human and yeast CTDs undergo cooperative liquid phase separation at increasing protein concentration, with the shorter yeast C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6022f59c-84d0-52e9-af03-53f6862d29bd
DOI: 10.1101/316372

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA polymerase II clustering through CTD phase separationDOI 10.1101/316372Read

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcriptionSemantic proximity Read

Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription.Semantic proximity Read

MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase SeparationSemantic proximity Read

Distinct roles of hnRNPH1 low-complexity domains in splicing and transcriptionSemantic proximity Read

Investigating the Context-Dependent Phase Separation of Human HOX Transcription FactorsSemantic proximity Read

Dynamic and Selective Low-Complexity Domain Interactions Revealed by Live-Cell Single-Molecule ImagingSemantic proximity Read

Liquid-like transcription condensates locally constrain chromatin in living human cellsSemantic proximity Read

Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localizationSemantic proximity Read

Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase.Semantic proximity Read

CDK12 condensation in nuclear speckles confers sensitivity to cyclin K molecular glue degradersSemantic proximity Read

Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcriptionSemantic proximity Read

Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicingSemantic proximity Read