Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.

doi:10.1111/cts.70698

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Article

Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.

Clinical and translational science - 1 Aug 2026

Pippis Christina A, Lopez-Medina Ana I, Chahal Choudhary Anwar A, Luzum Jasmine A

Abstract excerpt

Drug-induced QTc prolongation (diQTP) is a major risk factor for torsades de pointes and sudden cardiac death. This study evaluated whether carriers of the G allele of the NOS1AP rs10494366 T > G variant have greater risk for diQTP when prescribed high-risk QT-prolonging medications. A retrospective case-control analysis was conducted using the Michigan Genomics Initiative (MGI) biobank, linking genotype and...

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PMID: 42572225
DOI: 10.1111/cts.70698
PMCID: PMC13454358

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NOS1AP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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