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Article

A NOS1AP gene variant is associated with a paradoxical increase of the QT-interval shortening effect of digoxin.

The pharmacogenomics journal - 1 Feb 2022

Soroush Negin, Aarnoudse Albert-Jan, Kavousi Maryam, Kors Jan A, Ikram M Arfan, Newton-Cheh Christopher, Ahmadizar Fariba, Stricker Bruno H

Abstract excerpt

Digoxin is characterized by a small therapeutic window and a QT-interval shortening effect. Moreover, it has been shown that the genetic variants of the nitric oxide synthase-1 adaptor protein (NOS1AP) gene are associated with QT-interval prolongation. We investigated whether the rs10494366 variant of the NOS1AP gene decreases the QT-interval shortening effect of digoxin in patients using this drug. We included...

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Adaptor Proteins, Signal Transducing
Cardiotonic Agents
Digoxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrocardiography

Follow-Up Studies

Long QT Syndrome

Longitudinal Studies

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PMID: 34616002
DOI: 10.1038/s41397-021-00256-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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A NOS1AP gene variant is associated with a paradoxical increase of the QT-interval shortening effect of digoxin.PMID 34616002Read ↗

The NOS1AP gene rs10494366 common genetic variant does not modify the risk of sudden cardiac death in users of digoxin.Semantic proximity Read ↗

Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.Semantic proximity Read ↗

Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation.Semantic proximity Read ↗

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Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.Semantic proximity Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

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Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea.Semantic proximity Read ↗

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