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Article

The NOS1AP gene rs10494366 common genetic variant does not modify the risk of sudden cardiac death in users of digoxin.

British journal of clinical pharmacology - 1 Sept 2024

Soroush Negin, Aarnoudse Albert-Jan, Kavousi Maryam, Kors Jan A, Ikram M Arfan, Stricker Bruno H, Ahmadizar Fariba

Abstract excerpt

AIMS: Common genetic variations in the nitric oxide synthase-1 adaptor protein (NOS1AP) gene are associated with QT-interval prolongation. In a previous study, we observed an association between the rs10494366 variant of this gene and an increased QT-interval shortening in digoxin users. As QT-interval shortening is a risk factor for sudden cardiac death (SCD), in this study, we investigated whether the...

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PMID: 38822495
DOI: 10.1111/bcp.16130

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The NOS1AP gene rs10494366 common genetic variant does not modify the risk of sudden cardiac death in users of digoxin.PMID 38822495Read ↗

A NOS1AP gene variant is associated with a paradoxical increase of the QT-interval shortening effect of digoxin.Semantic proximity Read ↗

Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.Semantic proximity Read ↗

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.Semantic proximity Read ↗

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Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.Semantic proximity Read ↗

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.Semantic proximity Read ↗

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