Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.

Circulation - 4 Apr 2017

Strauss David G, Vicente Jose, Johannesen Lars, Blinova Ksenia, Mason Jay W, Weeke Peter, Behr Elijah R, Roden Dan M, Woosley Ray, Kosova Gulum, Rosenberg Michael A, Newton-Cheh Christopher

Abstract excerpt

BACKGROUND: Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications. The contribution of common genetic variants previously associated with baseline QT interval to drug-induced QT prolongation and arrhythmias is not known. METHODS: We tested the hypothesis that a weighted combination of common genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Long QT Syndrome

Share to Pilot Projects

Share to Polymorphism, Single Nucleotide

Share to Risk Assessment

Share to Torsades de Pointes

Source

Open in PubMed Open full text

Identifiers

PMID: 28213480
DOI: 10.1161/CIRCULATIONAHA.116.023980
PMCID: PMC5380476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.PMID 28213480Read ↗

Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.Semantic proximity Read ↗

A polygenic predictor of baseline QTc is associated with sotalol-induced QT prolongationSemantic proximity Read ↗

Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.Semantic proximity Read ↗

Polygenic Risk Score predicts QTc-prolongation and Short-Term Mortality in Patients using QT-prolonging Psychoactive MedicationsSemantic proximity Read ↗

Genetic and Molecular Aspects of Drug-Induced QT Interval ProlongationSemantic proximity Read ↗

Genetics of congenital and drug-induced long QT syndromes: current evidence and future research perspectives.Semantic proximity Read ↗

Drug‐ and non‐drug‐associated QT interval prolongationSemantic proximity Read ↗

Evaluating the impact of SDHAF3 p.F53L genetic variant on clinically significant QTc prolongation in patients prescribed high-risk medications: a retrospective pharmacogenetic study.Semantic proximity Read ↗

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update.Semantic proximity Read ↗

Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study.Semantic proximity Read ↗

Genotype and severity of long QT syndrome.Semantic proximity Read ↗

Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.