Article
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.
PloS one - 1 Jan 2013
Behr Elijah R, Ritchie Marylyn D, Tanaka Toshihiro, Kääb Stefan, Crawford Dana C, Nicoletti Paola, Floratos Aris, Sinner Moritz F, Kannankeril Prince J, Wilde Arthur A M, Bezzina Connie R, Schulze-Bahr Eric, Zumhagen Sven, Guicheney Pascale, Bishopric Nanette H, Marshall Vanessa, Shakir Saad, Dalageorgou Chrysoula, Bevan Steve, Jamshidi Yalda, Bastiaenen Rachel, Myerburg Robert J, Schott Jean-Jacques, Camm A John, Steinbeck Gerhard, Norris Kris, Altman Russ B, Tatonetti Nicholas P, Jeffery Steve, Kubo Michiaki, Nakamura Yusuke, Shen Yufeng, George Alfred L, Roden Dan M
Abstract excerpt
Marked prolongation of the QT interval on the electrocardiogram associated with the polymorphic ventricular tachycardia Torsades de Pointes is a serious adverse event during treatment with antiarrhythmic drugs and other culprit medications, and is a common cause for drug relabeling and withdrawal. Although clinical risk factors have been identified, the syndrome remains unpredictable in an individual patient....
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