Article
Common candidate gene variants are associated with QT interval duration in the general population.
Journal of internal medicine - 1 Apr 2009
Marjamaa A, Newton-Cheh C, Porthan K, Reunanen A, Lahermo P, Väänänen H, Jula A, Karanko H, Swan H, Toivonen L, Nieminen M S, Viitasalo M, Peltonen L, Oikarinen L, Palotie A, Kontula K, Salomaa V
Abstract excerpt
OBJECTIVES: QT interval prolongation is associated with increased risk of sudden cardiac death at the population level. As 30-40% of the QT-interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population-based sample. METHODS: We genotyped 12 common LQTS and NOS1AP genetic variants in Health 2000, an epidemiological sample of 5043...
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