Article

Polygenic Risk Score predicts QTc-prolongation and Short-Term Mortality in Patients using QT-prolonging Psychoactive Medications

2024-07-25

Abstract excerpt

<h4>Background</h4> There is a genetic component to the QT-interval. This study investigated whether a polygenic risk score for QTc (PRS QTc ) could predict ΔQTc and short-term mortality in first-time users of QT-prolonging medications (QTPM) with a known risk of Torsade de Pointes. <h4>Methods</h4> First-time users of psychoactive QTPM in the Copenhagen Hospital Biobank and the Danish Blood Donor Study from 2009-...

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Literature Corpus work: 89f59e55-39f6-52ee-8779-6e412760c81d
DOI: 10.1101/2024.07.24.24310940

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