Article
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.
International journal of epidemiology - 1 Oct 2008
Tobin Martin D, Kähönen Mika, Braund Peter, Nieminen Tuomo, Hajat Cother, Tomaszewski Maciej, Viik Jari, Lehtinen Rami, Ng G Andre, Macfarlane Peter W, Burton Paul R, Lehtimäki Terho, Samani Nilesh J
Abstract excerpt
BACKGROUND: A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have longer resting QTc and are more likely than men to develop drug-induced QT prolongation. Recent studies have shown association between resting QTc and a common variant (rs10494366) of the NOS1 regulator, NOS1AP. We investigated the association between rs10494366 in NOS1AP and QTc,...
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