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Article

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.

International journal of epidemiology - 1 Oct 2008

Tobin Martin D, Kähönen Mika, Braund Peter, Nieminen Tuomo, Hajat Cother, Tomaszewski Maciej, Viik Jari, Lehtinen Rami, Ng G Andre, Macfarlane Peter W, Burton Paul R, Lehtimäki Terho, Samani Nilesh J

Abstract excerpt

BACKGROUND: A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have longer resting QTc and are more likely than men to develop drug-induced QT prolongation. Recent studies have shown association between resting QTc and a common vari...

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Source

Identifiers

PMID: 18511491
DOI: 10.1093/ije/dyn091

Genes

NOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18511491-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.PMID 18511491Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing.Semantic proximity Read ↗

Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

Common candidate gene variants are associated with QT interval duration in the general population.Semantic proximity Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population.Semantic proximity Read ↗

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.Semantic proximity Read ↗

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).Semantic proximity Read ↗

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