Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

doi:10.1016/j.jacc.2012.03.031

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Article

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

Journal of the American College of Cardiology - 28 Aug 2012

Jamshidi Yalda, Nolte Ilja M, Dalageorgou Chrysoula, Zheng Dongling, Johnson Toby, Bastiaenen Rachel, Ruddy Suzanne, Talbott Daniel, Norris Kris J, Snieder Harold, George Alfred L, Marshall Vanessa, Shakir Saad, Kannankeril Prince J, Munroe Patricia B, Camm A John, Jeffery Steve, Roden Dan M, Behr Elijah R

Abstract excerpt

OBJECTIVES: This study sought to determine whether variations in NOS1AP affect drug-induced long QT syndrome (LQTS). BACKGROUND: Use of antiarrhythmic drugs is limited by the high incidence of serious adverse events including QT prolongation and torsades de pointes. NOS1AP gene variants play a role in modulating QT intervals in healthy subjects and severity of presentation in LQTS. METHODS: This study carried out...

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Identifiers

PMID: 22682551
DOI: 10.1016/j.jacc.2012.03.031
PMCID: PMC3753216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.PMID 22682551Read ↗

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