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Article

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation.

Pharmacogenetics and genomics - 1 Apr 2009

van Noord Charlotte, Aarnoudse Albert-Jan L H J, Eijgelsheim Mark, Sturkenboom Miriam C J M, Straus Sabine M J M, Hofman Albert, Kors Jan A, Newton-Cheh Christopher, Witteman Jacqueline C M, Stricker Bruno H Ch

Abstract excerpt

OBJECTIVES: To study whether NOS1AP single nucleotide polymorphisms (SNPs), rs10494366 T>G and rs10918594 C>G, modify the heart-rate-corrected QT (QTc) prolonging effect of calcium channel blockers. BACKGROUND: Common variation in the NOS1AP gene has been associated with QT interval variation in several large population samples. NOS1 is presumed to influence intracellular calcium. METHODS: The prospective...

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Identifiers

PMID: 19247217
DOI: 10.1097/FPC.0b013e328324e556

Genes

NOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation.PMID 19247217Read ↗

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