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Article

Association of Alzheimer's disease risk variants on the PICALM gene with PICALM expression, core biomarkers, and feature neurodegeneration.

Aging - 7 Nov 2020

Xu Wei, Tan Chen-Chen, Cao Xi-Peng, Tan Lan

Abstract excerpt

It is still unclear how PICALM mutations influence the risk of Alzheimer's disease (AD). We tested the association of AD risk variants on the PICALM gene with PICALM expression and AD feature endophenotypes. Bioinformatic methods were used to annotate the functionalities and to select the tag single nucleotide polymorphisms (SNPs). Multiple regressions were used to examine the cross-sectional and longitudinal...

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Identifiers

PMID: 33170153
DOI: 10.18632/aging.103814
PMCID: PMC7695360

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