Article
The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects.
Cerebral cortex (New York, N.Y. : 1991) - 1 Nov 2012
Sabuncu Mert R, Buckner Randy L, Smoller Jordan W, Lee Phil Hyoun, Fischl Bruce, Sperling Reisa A
Abstract excerpt
Late-onset Alzheimer's disease (AD) is 50-70% heritable with complex genetic underpinnings. In addition to Apoliprotein E (APOE) ε4, the major genetic risk factor, recent genome-wide association studies (GWAS) have identified a growing list of sequence variations associated with the disease. Building on a prior large-scale AD GWAS, we used a recently developed analytic method to compute a polygenic score that...
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