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Article

CAST controls presynaptic sequestration of Rab6 in neurons.

Molecular brain - 10 Jul 2026

Hida Yamato, Shimada Atsushi, Kim Yeon-Jeong, Kato-Murayama Miyuki, Shirouzu Mikako, Ohtsuka Toshihisa

Abstract excerpt

CAST is a core active zone scaffold protein, yet its role in Rab6-dependent trafficking remains unclear. Here, we identify the coiled-coil domain of CAST (CC10) as a direct Rab6-binding module and show that CAST selectively interacts with the GTP-bound form of Rab6 in both heterologous cells and neurons. Biochemical mapping, isothermal titration calorimetry, and bimolecular fluorescence complementation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42426838
DOI: 10.1186/s13041-026-01330-1
PMCID: PMC13371527

Genes

CAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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