Article

Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex

2020-04-18

Abstract excerpt

Rubicon is a potent negative regulator of autophagy and a potential target for autophagy-inducing therapeutics. Rubicon-mediated inhibition of autophagy requires the interaction of the C-terminal Rubicon homology (RH) domain of Rubicon with Rab7-GTP. Here we report the 2.8 Å crystal structure of the Rubicon RH domain in complex with Rab7-GTP. Our structure reveals a novel fold for the RH domain built around four z...

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Literature Corpus work: f6b22c5c-7303-5ae1-9428-bc9b6b0367ef
DOI: 10.1101/2020.04.18.048462

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